Publications-Sulab

2025

53. Wang, L.#, Xie, J.#, Gong, T.#, Wu, H.#, Tu, Y.#, Peng, X.#, Shang, S.#, Jia, X.#, Ma, H.#, Zou, J.#, Xu, S.#, Zheng, X.#, Zhang, D.#, Liu, Y.#, et al, Sun, S.*, Zhou, X.*, Su, Z.*, Cryo-EM reveals mechanisms of natural RNA multivalency. Science, 2025, adv3451.

52. Wang, L.#, Xie, J.#, Zhang, C.#, Zou, J., Huang, Z., Shang, S., Chen, X., Yang, Y., Liu, J., Dong, H., Huang, D.*, Su, Z.* Structural basis of circularly permuted group II intron self-splicing. Nat. Struct. Mol. Biol., 2025, 1-10.

51. Jia, X.#, Ma, H.#, Zhang, C., Luo, B., Frandsen, J.K., Watkins, A.M., Li, K., Dong, H., Yang, Y.*, Henkin, T.M.*, Su, Z.* Insertions in tRNA and T-box RNA modulate ligand recognition and translational regulation, 2025.

50. Wu, X.#, Luo, Y.#, Feng, S.#, Ma, H.#, Ke, B.*, Wang, K.*, Su, Z.*, Yang, D.*, Structural and membrane interactions of human OAT1 in complex with clinical used drugs, Sci. Adv., 2025, 11(7):eads5405.

49. Yong, X.#, Jia, G.#, Yang, Q.#, Zhou, C.#, Zhang, S., Deng, H., Billadeau, D.D., Su, Z.*, Jia, D.*, Cryo-EM structure of the BLOC-3 complex provides insights into the pathogenesis of Hermansky-Podlak syndrome, Nat. Commun., 2025, 16(1), 2967.

48. Yang, J.#, Hong, W.#, Shi, H.#, He, C.#, Lei, H.#, Zhou, Y.#, Yang, H.#, et al., Sun, Q.*, Lu, S.*, Wang, Z.*, Wang, Y.*, Lu, G.*, Li, W.*, Wei, X.*, A trivalent recombinant protein vaccine induces a cross-neutralization response against XBB lineage and JN.1 subvariants in preclinical and clinical trials. Nat. Commun., 2025, 15 (1): 10778

2024: 47. Chen, X.#, Wang, L.#, Xie, J.#, Nowak, J.S., Luo, B., Zhang, C., Jia, G., Zou, J., Huang, D., Glatt, S., Yang, Y., Su, Z.*, RNA sample optimization for cryo-EM analysis. Nat. Protoc., 2024, 1-44.; 46. Bu, F., et al., Westhof, E.*, Miao, Z.*, RNA-puzzles round V: Blind predictions of 23 RNA structures. Nat. Methods, 2024, 1-13.; 45. Lu, K.#, Luo, B.#, Tao, X.#, Luo, Y., Li, H., Xie, Y., Zhao, Z., Xia, W.*, Su, Z.*, Mao, Z.*, Complex structure and activation mechanism of arginine kinase McsB by McsA. Nat. Chem. Biol., 2024, 1-10.; 44. Deng, H.#, Jia, G.#, Zhao, L.#, Tang, Y.#, Li, P.#, Yang, Q., Zhao, J., Wang, J., Tu, Y., Yong, X., Zhang, S., Mo, X., Billadeau, D.D., Su, Z.*, Jia, D.*, WDR11 complex is a receptor for acidic cluster-containing cargo proteins. Cell, 2024, 187(16):4272-4288.; 43. Lyu, Y.#, Fu, C.#, Ma, H.#, Su, Z.*, Sun, Z.*, Zhou, X.*, Engineering of a mammalian VMAT2 for cryo-EM analysis results in non-canonical protein folding. Nat. Commun., 2024, 15: 6511.; 42. Ren, W.#, Hong, W.#, Yang, J.#, Zou, J.#, et al., Zhang, K.*, Dai, L.*, Lu, S.*, Wei, X.*, SARS-CoV-2 Delta and Omicron variants resist spike cleavage by human airway trypsin-like protease. J. Clin. Invest., 2024, 134(18):e174304.; 41. Tong, Z.#, Tong, J.#, Lei, W.#, et al., Lou, J.*, Gao, G.F.*, Deciphering a reliable synergistic bispecific strategy of rescuing antibodies for SARS-CoV-2 escape variants, including BA.2.86, EG.5.1 and JN.1. Cell Rep., 2024, 43(6).; 40. Hong, T.#, Luo, Q.#, Ma, H.#, Wang, X.#, Li, X., Shen, C., Pang, J., Wang, Y., Chen, Y., Zhang, C., Wang, X., Su, Z.*, Dong, H.*, Tang, X.*, Cryo-EM reveals the mechanism of TPR-CHAT negative regulation of CRISPR-Cas7-11. Signal Transduct. Target. Ther., 2024, 9(1), 111.; 39. Yang, L.#, Chen, Y.#, Chang, S.#, Wang, X., Zhang, C., Zhang, Z., Ding, B.-S., Su, Z.*, Dong, H.*, Tang, X.*, Structural insights into the activation of the divisome complex FtsWIQLB. Cell Discov., 2024, 10(1): 2.; 38. Zhu, Y.#, Luo, B.#, Mou, X.#, Song, Y.#, Zhou, Y., Luo, Y., Sun, B., Luo, Y., Tang, H.*, Su, Z.*, Bao, R.*, Pseudomonas aeruginosa regulator PvrA binds simultaneously to multiple pseudo-palindromic sites for efficient transcription activation. Sci. China Life Sci., 2024, 67(5):900-912.

2023: 37. Lai, Y.#, Zhao, C.#, Tian, Z.#, Wang, C.#, Fan, J.#, et al., Liu, C.*, Brunger, A.T.*, Diao, J.*, Neutral lysophosphatidylcholine mediates α-synuclein induced synaptic vesicle clustering. Proc. Natl. Acad. Sci. USA, 2023, 120(44): e2310174120.; 36. Kretsch, R.C.*, et al., Moult, J.*, Kryshtafovych, A.*, RNA target highlights in CASP15: Evaluation of predicted models by structure providers. Proteins: Structure, Function, and Bioinformatics, 2023, 91(12), 1600-1615.; 35. Wang, Y.#, Zhang, C.#, Luo, Y., Ling, X., Luo, B., Jia, G., Su, D., Dong, H. and Su, Z.*, Cryo-EM structure of the nucleocapsid-like assembly of respiratory syncytial virus. Signal Transduct. Target. Ther., 2023, 8(1), 323.; 34. Xia, A.#, Yong, X.#, Zhang, C.#, Lin, G.#, Jia, G.#, Zhao, C.#, Wang, X.#, Hao, Y.#, et al., Zhou, R.*, Dong, H.*, Shao, Z.*, Yang, S.*, Cryo-EM structures of human GPR34 enable the discovery of selective antagonists. Proc. Natl. Acad. Sci. USA, 2023, 120(39): e230843512; 33. Liu, C., Zhang, H., Peng, X., Blackledge, M.S., Furlani, R.E., Li, H., Su, Z., Melander, R.J., Melander, C., Michalek, S., Wu, H.*, Small molecule attenuates bacterial virulence by targeting conserved response regulator. Mbio, 2023, e00137-23.; 32. Yong, X.#, Jia, G.#, Liu, Z.#, Zhou, C., Yi, J., Tang, Y., Chen, L., Chen, L., Wang, Y., Sun, Q., Billadeau, D.D., Su, Z.*, Jia, D.*, Cryo-EM structure of the Mon1-Ccz1-RMC1 complex reveals molecular basis of metazoan RAB7A activation. Proc. Natl. Acad. Sci. USA, 2023, 120(22): e2301725120.; 31. Tang, D.#, Jia, T.#, Luo, Y.#, Mou, B., Cheng, J., Qi, S., Yao, S., Su, Z.*, Yu, Y.*, Chen, Q.*, DnaQ mediates the diectional spacer acquisition in CRISPR-Cas system by a time-dependent mechanism. Innovation, 2023, 4(5):100495.; 30. Jia, X.^#, Pan, Z.^#, Yuan, Y.^#, Luo, B., Luo, Y., Mukherjee, S., Jia, G., Liu, L., Ling, X., Yang, X., Miao, Z., Wei, X., Bjnicki, J. M., Zhao, K.^* & Su, Z.^* Structural basis of sRNA RsmZ regulation of Pseudomonas aeruginosa virulence. Cell Res., 2023, 33:328-330; 29. Luo, B.# , Zhang, C.# , Ling, X., Mukherjee, S., Jia, G., Xie, J., Jia, X., Liu, L., Luo, Y., Jiang, L., Dong, H., Wei, X., Bujnicki, J.M., Su, Z.*, Cryo-EM reveals dynamics of Tetrahymena group I intron self-splicing. Nat. Catal., 2023, 6:298-309.; 28. Wang, Y.#, Ling, X.#, et al., Ma, J.*, Liu, C.*, Su, Z.*, Modular characterization of SARS-CoV-2 nucleocapsid protein domain functions in nucleocapsid-like assembly. Mol. Biomed., 2023, 4(1):16.

2022

27. Zhang, G.#, Guo, C.#, Wang, Y.#, Zhang, X.#, et al., Su, Z., Chen, P., Ren, Z., Yu, M., Qu, F., Luo, Y., Gou, L., Li, Q., Huang, Y.*, Ma, F.*, Yang, J.*, FTL004, an anti-CD38 mAb with negligible RBC binding and enhanced pro-apoptotic activity, is a novel candidate for treatments of multiple myeloma and non-Hodgkin lymphoma. J. Hematol. Oncol., 2022, 15:177.

26. Zhang, S.#, Fu, C.#, Luo Y.#, Xie, Q., Xu, T., Sun, Z.*, Su, Z.*, Zhou, X.*, Cryo-EM structure of a eukaryotic zinc transporter at low pH suggests its Zn²⁺ -releasing mechanism. J. Struct. Biol., 2023, 215(1):107926.

25. Sun, W., Yang, K., Wang, Z., Niu, M., Luo, T., Su, Z., Li, R.^* & Fu, Q.^* Ultrahigh Molecular Weight Polyethylene Lamellar‐Thin Framework on Square Meter Scale. Adv. Mater., 2022, 34, 2107941.

24. Ma, H., Pham, P., Luo, B., Rangan, R., Kappel, K., Su, Z.*, Das, R.*, Auto-DRRAFTER: Automated RNA modeling based on cryo-EM density. Methods Mol. Biol., 2023, 2568:193-211. Invited book chapter

23. Li, S., Palo, M. Z., Pintilie, G., Zhang, X., Su, Z., Kappel, K., Chiu, W.*, Zhang, K.* & Das, R.* Topological crossing in the misfolded Tetrahymena ribozyme resolved by cryo-EM. Proc. Natl. Acad. Sci. USA., 2022, 119(37), e2209146119.

22. He, C.#, Yang, J.#, Hong, W.#, Chen, Z.#, Peng, D.#, et al., Su, Z., Wei, Y., Cen, X., Tanaka, Y., Song, X.*, Lu, S.*, Peng, X.*, Lu, G.*, Wei, X.*, A self-assembled trimeric protein vaccine induces protective immunity against Omicron variant. Nat. Commun., 2022, 13(1):1-14.

21. Xu. Y.#, Jia, G.#, Li, T.#, Zhou, Z.#, Luo, Y., Chao, Y., Bao, J., Su, Z.*, Qu, Q.* and Li, D.*, Molecular insights into biogenesis of glycosylphosphatidylinositol anchor proteins. Nat. Commun. 2022, 13(1):2617.

20. Li, Y.#, Lu, S.#, Gu, J.#, Xia, W., Zhang, S., Zhang, S., Wang, Y., Zhang, C., Sun, Y., Lei, J., Liu, C., Su, Z.*, Yang, J.*, Peng, X.* and Li, D.*, SARS-CoV-2 impairs the disassembly of stress granules and promotes ALS-associated amyloid aggregation. Protein Cell, 2022, 13(8):602-614.

19. Hong, W.#, Yang, J.#, Zou, J.#, Bi, Z.#, He, C.#, Lei, H.#, et al., Su, Z., Tong, A.*, Lu, S.*, Peng, X.*, Wei, X.*, Histones released by NETosis enhance the infectivity of SARS-CoV-2 by bridging the spike protein subunit 2 and sialic acid on host cells. Cell. Mol. Immunol., 2022, 19(5):577-587.

18. Ma, H., Jia, X., Zhang, K. and Su, Z.*, Cryo-EM advances in RNA structure determination. Signal Transduct. Target. Ther., 2022, 7(1):58.

17. Wang, Y., Binning, J.M., Pintilie, G.D., Chiu, W., Amarasinghe, G.K.*, Leung, D.W.* and Su, Z.*, Cryo-EM analysis of Ebola virus nucleocapsid-like assembly. STAR Protoc., 2022, 3(1):101030

2021

16. Lyu, J., Yang, M., Zhang, C., Luo, Y., Qin, T., Su, Z., Huang, Z.*, DNA nanostructures directed by RNA clamps. Nanoscale., 2021, 13(47):19870-19874.

15. Yuan, Y.# , Jia, G.# , Wu, C.# , Wang, W.# , Cheng, L., Li, Q., Li, Z., Luo, K., Yang, S., Yan, W.*, Su, Z.* and Shao, Z.*, Structures of signaling complexes of lipid receptors S1PR1 and S1PR5 reveal mechanisms of activation and drug recognition. Cell Res., 2021, 31(12):1263-1274.

14. Shen, L., Su, Z., Yang, K., Wu, C., Becker, T., Bell-Pedersen, D., Zhang, J., Sachs, M.S.*, Structure of the translating Neurospora ribosome arrested by cycloheximide. Proc. Natl. Acad. Sci. USA., 2021, 118(48):e2111862118.

13. Su, Z.#,*, Zhang, K.# , Kappel, K# ., Li, S., Palo, M.Z., Pintilie, G.D., Rangan, R., Luo, B., Wei, Y., Das, R.* and Chiu, W.*, Cryo-EM structure of full-length Tetrahymena ribozyme at 3.1 Å resolution. Nature, 2021, 596(7873): 603-607.

12. Torabi, S.F., Chen, Y.L., Zhang, K., Wang J., DeGregorio, S.J., Vaidya, A.T., Pabit, S.A., Su, Z., Chiu, W.*, Pollack, L.*, Steitz, J.A.*, Structural analyses of an RNA stability element interacting with the poly(A) tail. Proc. Natl. Acad. Sci. USA., 2021, 118(14):e2026656118.

2020 and earlier

11. Kappel, K.#, Zhang, K.#, Kappel, K.#, Zhang, K.#, Su, Z.#, Watkins, A.M., Kladwang, W., Li, S., Pintilie, G.D., Topkar, V.V., Rangan, R., Zheludev, I.N., Yesselman, J.D., Chiu, W.*, & Das, R.* Accelerated cryo-EM-guided determination of three-dimensional RNA-only structures. Nat.Methods, 2020, 17, 699-707.

10. Pintilie, G.D.#, Zhang, K.#, Su, Z., Li, S., Schmid, M.F., Chiu, W.* Measurement of atom resolvability in cryoEM maps with Q-scores. Nat.Methods, 2020, 17(3), 328-334.

9. Zhang, K.#, Li, S.#, Kappel, K.#, Pintilie, G.D., Su, Z., Mou, T.-C., Schimid, M.F., Das, R.*, & Chiu, W.* Cryo-EM structure of 40-kDa SAM-IV riboswitch RNA at 3.7 Å resolution. Nat. Commun. , 2019, 10(1), 1-6.

8. Li, S. # , Su, Z. # , et al., Chiu, W.* and Zhang, J.*, Structural basis of amino acid surveillance by higher order tRNA-mRNA interactions. Nat. Struct. Mol. Biol., 2019, 26(12):1094-1105.

7. Zhang, K.#, Keane, S.#, Su, Z., Irobalieva, R.N., Chen, M., Van, V., Sciandra, C.A., Marchant, J., Heng, X., Schmid, M.F., Case, D.*, Ludtke, S.J.*, Summers, M.F.*, & Chiu, W.* Structure of the 30 kDa HIV-1 RNA dimerization signal by a hybrid cryo-EM, NMR and molecular dynamics approach. Structure, 2018, 26(3), 490-498.

6. Su, Z.^#, Wu, C.^#, Shi, L., Luthra, P., Pintilie, G.D., Britney, J., Porter, J.R., Ge, P., Chen, M., Liu, G., Frederick, T.E., Binning, J.M., Bowman, G.R., Zhou, Z.H., Basler, C.F., Gross, M.L., Leung, D.W., Chiu, W.^*, Amarasinghe, G.K.^* Electron cryo-microscopy structure of Ebola nucleoprotein reveals a mechanism for nucleocapsid-like assembly. Cell, 2018, 172(5), 966-978.

5. Su, Z.#, Zhang, Y.#, Gendron, T.F.#, Bauer, P.O.#, Chew, J., Yang, W.Y., Fostvedt, E., Jansen-West, K., Belzil, V.V., Desaro, P., Johnston, A., Overstreet, K., Boeve, B.F., Dickson, D., Floeter M.K., Traynor, B.J., Morelli, C., Ratti, A., Silani, V., Rademakers, R., Brown, R.H., Rothstein, J.D., Boylan, K., Petrucelli, L.* & Disney, M.D.* Discovery of a biomarker and Lead small molecules to target r(GGGGCC)-Associated defects in c9FTD/ALS. Neuron, 2014, 83(5), 1043-1050.

4. Su, Z., Yeagley, A.A., Su, R., Peng, L. and Melander, C.* Structural studies on 4,5-Disubstituted-2-Aminoimidazole-based biofilm modulators that suppress bacterial resistance to β-Lactams. ChemMedChem., 2012, 7(11), 2030-2039.

3. Su. Z#, Peng. L#, Melander. C.* A modular approach to the synthesis of 1, 4, 5-substituted-2-aminoimidazoles. Tetrahedron Lett., 2012,53 (10), 1204-1206.

2. Su, Z., Peng, L., Worthington, R. J., and Melander, C.* Evaluation of 4,5-Disubstituted-2-Aminoimidazole conjugates for antibiofilm/antibiotic resensitization activity against MRSA and acinetobacter baumannii. ChemMedChem, 2011, 6(12), 2243-2251.

1. Su, Z., Rogers, S. A., McCall, W. S., Smith, A. C., Ravishankar, S., Mullikin, T. and Melander, C.*, A nitroenolate approach to the synthesis of 4,5-disubstituted-2-aminoimidazoles: pilot library assembly and screening for antibiotic and antibiofilm activity. Org. Biomol. Chem., 2010, 8(12):2814-2822.

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